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Mental health continues to be a pressing issue worldwide, with depression significantly impacting individuals and society.

While conventional treatments help many, some seek natural alternatives or supplements to aid symptom management. This article explores a promising category of such tools called nootropics.

Nootropics, also known as smart drugs, refer to compounds aimed at optimizing brain function and cognition.

An emerging area of research has explored which nootropic substances may also lighten the mood. 

Certain nootropics exhibit pharmacological properties targeting neurotransmitter systems involved in depression.

This article explores some of the most promising nootropic options for easing depressive symptoms either alongside conventional treatments or on their own.

What are Nootropics?

Nootropics, sometimes called smart drugs, refer to supplements aimed at optimizing or enhancing cognitive functioning and mental performance. 

The term was coined in 1972 by Romanian scientist Dr. Corneliu Giurgea to describe psychoactive agents that boost aspects of memory, motivation, and mood without major side effects. 

Nootropics work through various mechanisms such as increasing blood flow and oxygen consumption in the brain, supporting neuroplasticity, protecting neurons from toxicity, and modulating key neurotransmitter systems involved in mood regulation and cognition. 

Common categorizations of nootropics include racetams, cholinergic, antioxidants, vasodilators, and herbs/nutrients like Rhodiola Rosea and Bacopa Monnieri which have demonstrated neuroprotective benefits. 

Proper dosing and sourcing from reputable brands are important when using nootropics to ensure safety.

What are the Signs and Symptoms of Depression?

Image Credit: magicmind.com

Before using nootropics for depression, it is important to understand what depression actually is.

Depression is more than just fleeting sadness; it’s a complex and pervasive mental health condition that affects millions worldwide.

It encompasses a persistent and pervasive sense of hopelessness, low energy, and a lack of interest or pleasure in activities that once brought joy. 

Unlike everyday sadness, depression can interfere significantly with daily life, impacting relationships, work, and overall well-being. 

Key indicators of depression include changes in appetite and sleep patterns, fatigue, difficulty concentrating, and even thoughts of self-harm or suicide in severe cases.

While sadness is a component, depression encompasses a broader spectrum of emotional, cognitive, and physical symptoms. 

At its core, depression involves a disruption in the delicate balance of neurotransmitters in the brain, particularly serotonin, dopamine, and norepinephrine.

These neurotransmitters play a crucial role in regulating mood, motivation, and emotional responses. 

Before exploring the potential benefits of nootropics, it’s essential to recognize the depth and complexity of depression and seek professional guidance for a comprehensive approach to mental well-being.

Do Nootropics Help With Depression?

Depression, as discussed earlier, not only affects mood but also takes a toll on cognitive and mental performance. Lowered motivation is a common symptom, making it challenging to complete tasks.

Scientific studies suggest that addressing these aspects, particularly regulating anxiety and enhancing motivation, might contribute to regaining cognitive control amid depressive episodes.

Nootropics emerged as a potential ally in this battle against depression. Operating through various pathways, such as neurotransmitter systems (dopaminergic, glutamatergic/cholinergic, and serotonergic), hormones, transduction systems, and brain metabolism, nootropics offer a spectrum of cognitive benefits. 

These include improvements in memory, attention, creativity, and motivation, which collectively contribute to alleviating depressive symptoms.

Depression’s impact on memory is profound, slowing down information processing and impeding the encoding and storage of data for future recall. This interference extends to learning new information. 

Nootropics, by enhancing memory function, may counteract these effects, facilitating better information processing speed, storage, and recall even during mood-related challenges.

Moreover, certain nootropics showcase neuroprotective antioxidative properties, countering oxidative stress and neuroinflammation implicated in depression’s pathophysiology. 

Compounds like curcumin from turmeric and lion’s mane mushroom, known for their robust antioxidant capacity, may play a role in reducing the burden of oxidative stress on neurons, offering a holistic approach to addressing depression’s complex mechanisms.

While additional research is warranted in this area, a study published in the Journal of International Medical Research aimed to compare the efficacy of selective serotonin reuptake inhibitors (SSRIs) with that of nootropic drugs in reducing anxiety and depressive symptoms in post-stroke patients.

The study involved 44 post-stroke patients with depression, ranging in age from 45 to 75 years. Out of these, 20 were treated with SSRIs, while the remaining 24 received nootropic drugs.

Their findings suggested that the administration of nootropic drugs could be a valid therapeutic strategy for managing post-stroke patients experiencing mild to moderate anxiety or anxious-depressive syndrome.

In another recent scientific review published in 2021, the effectiveness of nootropics with botanical origins in addressing mood-related issues was explored.

The study focused on botanicals with recognized nootropic effects and their impact on mood, including anxiety and depression.

The findings of the review indicated that numerous nootropics exhibited positive effects on sleep and mood regulation, suggesting that nootropics could be potential contributors to alleviating symptoms associated with anxiety and depression.

Promising Individual Nootropics

Promising Individual Nootropics
Image Credit: vagarights.com

Here are several nootropics known for their potential in alleviating depression:

1. Rhodiola Rosea

Rhodiola Rosea, originating from Europe and Asia, is one of the most promising nootropics for addressing depression and stress-related issues. 

It has been recognized as an herbal antidepressant and an adaptogen, which means it may assist individuals in coping with the effects of stress.

Beyond its adaptogenic prowess, Rhodiola Rosea’s anti-inflammatory and antioxidant properties further position it as a comprehensive solution for safeguarding the brain against the impact of stress and depressive conditions.

In a recent study involving 89 individuals suffering from mild to moderate depression, the impact of Rhodiola Rosea was investigated. 

The findings revealed that participants who consumed daily doses ranging from 340 to 680 mg of Rhodiola Rosea exhibited substantial enhancements in their depression levels compared to those administered a placebo.

2. Ashwagandha

Ashwagandha, scientifically known as Withania somnifera, emerges as an herbal powerhouse deeply rooted in the ancient traditions of Ayurvedic medicine. 

Revered as Indian ginseng, this nootropic has stood the test of time, offering holistic health benefits for countless individuals over the centuries.

Having played a pivotal role in addressing various health concerns, including stress, anxiety, and mood disorders, Ashwagandha is celebrated for its prowess in regulating the body’s stress response and fostering a sense of tranquility. 

It boasts active compounds such as withanolides, alkaloids, and saponins, which are believed to underpin its therapeutic effects.

Ashwagandha’s distinctive properties are thought to exert an influence on neurotransmitter pathways, the endocrine system, and the body’s inflammatory response, making it a promising natural nootropic against depression.

3. Lion’s Mane Mushroom

The lion’s mane mushroom (Hericium erinaceus) has gained popularity as a nootropic due to its neurogenerative and neuroprotective properties. 

It contains several compounds that may help depression, such as hericenones and erinacines.

The consumption of Lion’s Mane Mushroom has been linked to an augmentation in the production of Nerve Growth Factor (NGF), a crucial growth factor facilitating the development and regeneration of neurons in the brain. 

This heightened production of NGF holds promise for enhancing mood and mitigating symptoms of depression.

Moreover, Lion’s Mane Mushroom boasts anti-inflammatory properties, a feature that can contribute to stress and anxiety reduction—two factors intertwined with feelings of depression. 

In a research study conducted by Nagano and colleagues, the clinical effects of lion’s mane mushroom intake were investigated over a 4-week period. 

The focus of the study included examining the impact on menopause, depression, sleep quality, and general complaints. 

The findings of the research proved that the intake of lion’s mane mushrooms holds promise in potentially reducing symptoms of depression and anxiety. 

The accessibility of Lion’s Mane Mushroom in various forms, such as capsules, powders, and tinctures, makes it convenient to integrate into one’s daily routine for potential mental health benefits.

4. L-Theanine

L-Theanine, derived from tea leaves, emerges as a natural brain booster with potential antidepressant effects. 

Monks have utilized L-Theanine for centuries, appreciating its role in inducing a calm and relaxed state during meditation. 

Acting as a GABA agonist, L-Theanine influences the main inhibitory neurotransmitter, GABA, resulting in a calming effect on the central nervous system.

This mechanism reduces overall brain activity, eases muscle tension, and contributes to lowering blood pressure.

One distinctive feature of L-Theanine is its ability to inhibit the stress hormone cortisol.

By doing so, L-Theanine helps mitigate the physiological impacts of stress, offering a potential balance to mood during challenging periods. 

This natural compound’s multifaceted approach to inducing relaxation and reducing stress makes it an intriguing option for those seeking a mood boost through natural means.

5. Bacopa Monnieri

Bacopa monnieri, deeply rooted in traditional Ayurvedic practices, stands out as a natural nootropic with mental health benefits, including the potential to alleviate symptoms of depression. 

Known for its cognitive-enhancing properties, Bacopa monnieri has been integral to traditional medicine for centuries.

The herb exerts its positive influence on mental well-being by increasing serotonin levels in the brain. This neurotransmitter plays a pivotal role in mood regulation and anxiety reduction. 

Additionally, Bacopa monnieri enhances brain-derived neurotrophic factor (BDNF), a critical protein that supports neuron protection and strengthens synaptic connections.

Scientific studies corroborate the traditional wisdom surrounding Bacopa monnieri, suggesting its efficacy in improving cognitive function and serving as a complementary approach to managing symptoms of depression. 

Whether consumed as a supplement or brewed into a soothing tea, Bacopa monnieri aligns with a holistic perspective on mental wellness.

6. Gingko Biloba

Gingko Biloba, extracted from one of the oldest tree species on Earth, boasts a history dating back over 290 million years. 

Originating from China, this ancient botanical treasure has garnered attention for its potential as a nootropic for depression.

In a notable human study involving 136 older adults, Gingko Biloba extract showcased its potential to improve depressive symptoms. 

Moreover, when combined with an antidepressant, it contributed to a reduction in S100B levels, a marker associated with brain injury. 

Beyond its potential in combating depression, Gingko Biloba offers a spectrum of health benefits, including support for eye and vision health, migraine and headache alleviation, relief from PMS symptoms, and treatment for sexual dysfunction.

Scientific evaluations also highlight Gingko Biloba’s efficacy in addressing anxiety, stress, and symptoms related to Alzheimer’s disease and age-related cognitive decline.

This multifaceted ancient remedy continues to reveal its therapeutic potential, making it a valuable addition to the arsenal of nootropics for mental well-being.

7. Phosphatidylserine (PS)

Phosphatidylserine (PS) is a pivotal nootropic brain supplement with the capacity to enhance memory by supporting crucial brain chemicals such as dopamine, Nerve Growth Factor, and norepinephrine. 

In the context of depression, PS demonstrates its potential to induce consistent improvements, particularly in depressive symptoms, behavior, and memory, as evidenced by a small study involving 10 elderly women with depression.

Additional research reinforces the cognitive benefits of PS, emphasizing its supportive role in memory and overall cognitive function. 

This positions phosphatidylserine as a valuable supplement, particularly for individuals, especially aging individuals, experiencing memory-related challenges as part of their depressive symptoms. 

Whether taken as a standalone supplement or as part of a brain stack, phosphatidylserine stands out as a promising option for those seeking cognitive enhancement and relief from the impact of depression on memory.

8. Ginseng 

Ginseng, a popular nootropic, is celebrated not just for enhancing cognitive functions but also for its potential role in promoting mental well-being. 

Often embraced for its reputed ability to boost mental performance and alleviate stress, ginseng has also piqued interest as a possible remedy for depression.

Known to regulate mood, increase energy levels, and combat fatigue, ginseng comes in various forms such as powder, capsules, or tea. 

Its traditional roots in Chinese and Korean herbal medicines speak to its enduring popularity in holistic health practices. 

Many individuals turn to ginseng not only to sharpen their cognitive edge but also to harness its mood-enhancing properties.

While ginseng’s potential to mitigate depressive symptoms is widely discussed, it’s crucial to approach its usage with caution. 

Potential side effects, including dizziness, insomnia, headaches, and stomach upset, underscore the importance of consulting with a healthcare professional before incorporating ginseng into a depression management plan.

9. Omega-3 fatty acids

Omega-3 fatty acids, essential fats naturally present in specific foods, are an important nootropic and play a crucial role in supporting various bodily functions. 

They can be obtained from a range of food sources, including fatty fish like salmon, mackerel, herring, and sardines, as well as nuts and seeds like walnuts, chia seeds, and flaxseeds. 

Apart from their recognized benefits for overall health, including improvements in hair and skin health, omega-3 supplements are also explored for their potential in managing depression.

Scientific evidence also endorses the effectiveness of omega-3 fatty acids in the management of depression. 

In an eight-week clinical trial with 60 outpatients, the administration of 1000 mg of eicosapentaenoic acid (EPA), a key omega-3 fatty acid, showed results comparable to fluoxetine in relieving depressive symptoms. 

Notably, the combined treatment of EPA and fluoxetine exhibited superior outcomes compared to either treatment alone. 

Nootropic Stacks vs. Monotherapy

Monotherapy refers to using nootropics individually without combining them. While this can be effective, researchers have started exploring the benefits of nootropic “stacks,” which involve purposefully combining two or more compounds. 

Stacks are hypothesized to provide synergistic, complementary, and entourage effects by targeting multiple neurobiological pathways simultaneously.

It’s a strategy often adopted by individuals seeking cognitive improvement, including students, professionals, and athletes.

For instance, a stack designed to reduce stress and anxiety might include natural nootropics like Ashwagandha, Magnesium, and B vitamins. 

Another stack focusing on mood improvement and anxiety reduction might incorporate 5-HTP, St. John’s Wort, and L-theanine. 

While nootropic stacks offer potential cognitive benefits, it’s essential to acknowledge the associated drawbacks and risks.

Possible drawbacks include dependency, as some individuals may rely on nootropic stacks for normal functioning, experiencing withdrawal symptoms when not using them. 

Side effects, such as nausea, headaches, insomnia, and anxiety, may also occur with certain nootropics. 

Additionally, there’s a risk of drug interactions, potential tolerance development, misuse, high costs, and insufficient long-term studies on the safety and efficacy of nootropic stacks.

Support and Guidance with BetterHelp

BetterHelp offers a valuable resource for individuals dealing with depression. Their platform connects users with licensed mental health professionals who can provide guidance and support. 

BetterHelp’s experienced therapists can employ evidence-based techniques, personalized treatment plans, and a compassionate approach to help you navigate the challenges of depression. 

Through secure and confidential online sessions, you can engage in therapy at your own pace and on your own terms. 

Depression can be isolating, but with BetterHelp, you don’t have to face it alone, and you can take the first step toward healing and recovery.


Natural anti-depressant nootropics offer a promising avenue for individuals seeking cognitive support while addressing mood-related issues.

While clinical research is still emerging, preliminary human trials and observational studies consistently point to reductions in depressive thinking and improvements in mood, cognition, and well-being for individuals employing purposefully selected nootropic regimens.

However, it is essential to approach their use with caution, considering individual variations and potential interactions, and to consult with a healthcare professional for personalized advice.

Always prioritize safety and informed decision-making when exploring nootropic options for depression management.


1. Are there any side effects associated with natural antidepressant nootropics?

Natural anti-depressant nootropics are generally considered safe, with minimal side effects for the majority of users.

They have undergone clinical trials and are deemed safe for human consumption. However, individual responses may vary, and it’s advisable to monitor for any adverse effects.

2. Can nootropics be safely combined with antidepressants?

No, it is generally not advisable to mix nootropics with antidepressants. Even natural nootropics can potentially interact negatively with antidepressant medications.

Combining substances that influence neurotransmitter balance may lead to unpredictable outcomes. It is crucial to consult with a healthcare professional before considering any such combination.

3. Can nootropics be used as a standalone treatment for depression?

While natural anti-depressant nootropics may offer support for mood-related issues, they are not intended to replace conventional depression treatments.



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