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Every year in the United States, the staggering impact of mental health issues becomes evident as statistics reveal the extent of its prevalence. These health conditions continue to be a significant concern in the United States, impacting individuals across various aspects of their lives.

Approximately 19% of adults grapple with various forms of mental illness, underscoring the nationwide profound reach of psychological struggles. Among these individuals, 4.1% contend with serious mental illnesses that significantly affect their daily lives. 

This statistic is not unique to the US; the Mental Health Foundation’s findings reveal that in the UK alone, a staggering 70 million workdays are forfeited annually due to mental health issues.

Mixed Anxiety and depression is the prevailing mental disorder in Britain, with 7.8% of the population meeting its diagnostic criteria. This substantial loss of productivity carries a substantial financial burden, costing employers around £2.4 billion each year.

Within this context, anxiety, one of the prevalent mental disorders, can significantly contribute to poor mental health and reduced quality of life.

To address this issue, exploring innovative therapeutic avenues becomes imperative. Among these potential solutions, emerging research has spotlighted the role of Nicotinamide adenine dinucleotide (NAD) in managing anxiety.

Read on to know how possible Nicotinamide adenine dinucleotide may help with Anxiety.

What is NAD/NAD+?

NAD, or Nicotinamide Adenine Dinucleotide, is a coenzyme found in all living cells. NAD+ is its oxidized form, while NADH is the reduced form.

They are crucial in various biological processes, including energy metabolism, DNA repair, and cellular signaling. NAD+ is involved in redox reactions, transferring electrons between molecules to support cellular functions. 

The human body generates NAD naturally, but the coenzyme levels decline, causing cellular alterations associated with age-related conditions. Also, stress and difficulties in life can reduce the amount of NAD in your body. 

Studies indicate that individuals with significantly low NAD levels are susceptible to developing issues concerning addiction, anxiety, and other mental disorders.

However, innovative approaches, such as intravenous (IV) NAD delivery, present a convenient avenue to address anxiety by reinstating optimal NAD levels within the body.

IV NAD infusions refill your body’s NAD levels quickly. While NAD therapy improves anxiety symptoms, it also boosts your overall health. 

Discover the transformative potential of NAD with our team of certified professional therapists at BetterHelp. Take the step towards enhanced well-being today by connecting with our experts who are dedicated to guiding you on your journey to a better life.

What does a NAD IV treatment include?

A NAD IV treatment, also known as Nicotinamide Adenine Dinucleotide IV treatment, is a therapy that involves the intravenous administration of NAD.

During a NAD IV treatment, a healthcare professional administers a carefully controlled dose of NAD and a combination of complementary vitamins into the patient’s bloodstream through an intravenous infusion.

The vitamins combined are B-complex vitamins, Vitamin C, Vitamin B12, Glutathione, and Magnesium. This method allows for faster and more efficient absorption compared to oral supplementation. 

The treatment typically takes a few hours to complete, and patients may need multiple sessions depending on their specific health goals and the severity of their condition.

What’s the Process Like?

The process of NAD IV treatment typically includes several key steps:

1. Medical Assessment: Individuals undergo a comprehensive medical assessment before undergoing NAD IV treatment.

This assessment helps healthcare professionals determine whether the treatment suits the patient’s needs and medical history.

2. Pre-Treatment Preparation: Patients are advised to stay well-hydrated and maintain a balanced diet before the treatment. Adequate hydration helps facilitate the infusion process and minimize potential side effects.

3. IV Catheter Insertion: A trained medical professional inserts an intravenous (IV) catheter into a vein, usually in the arm. The IV catheter is the entry point for delivering the NAD solution directly into the bloodstream.

4. NAD Infusion: The NAD solution, which contains a highly bioavailable form of nicotinamide adenine dinucleotide, is administered through the IV catheter. Medical staff carefully monitor and control the infusion rate to ensure a safe and effective treatment process.

5. Treatment Duration: The duration of the NAD IV treatment can vary depending on factors such as the patient’s specific health goals and the clinic’s protocol. Sessions can last several hours, and multiple sessions may be recommended for optimal results.

6. Monitoring: Medical professionals closely monitor patients Throughout the infusion. Vital signs such as blood pressure, heart rate, and oxygen levels are regularly checked to ensure the patient’s safety and comfort.

7. Post-Treatment Care: Patients may be advised to continue staying hydrated and maintaining a healthy lifestyle after the infusion.

Follow-up appointments may be scheduled to assess the treatment’s effectiveness and make any necessary adjustments to the ongoing plan.

The Benefits of NAD IV

The potential benefits of NAD IV treatment are attributed to its role in cellular energy production and its involvement in various enzymatic reactions.

It’s believed that NAD helps support mitochondrial function, which is essential for cell energy production. Additionally, NAD is involved in DNA repair and gene expression regulation, contributing to cellular health and longevity.

Furthermore, NAD IV treatments have been proposed as a complementary approach to mental health support. NAD’s involvement in neurotransmitter synthesis and its potential to reduce inflammation could make it relevant to conditions like depression, Anxiety, and PTSD. 

NAD IV treatments have also been explored for their potential anti-aging effects. As we age, NAD levels tend to decline, impacting cellular function and contributing to aging. Some researchers and practitioners believe replenishing NAD levels through IV therapy could rejuvenate the body.

This restoration process enhances overall well-being and cultivates a sense of tranquility. Additionally, it sharpens focus and bolsters the capacity to navigate challenging circumstances.

Sometimes, NAD IV treatment may be combined with other therapies, such as counseling or lifestyle modifications, to maximize its effects and address broader health concerns.

Causes of low NAD levels

Image Credit: midcitytms.com

Several factors may cause the body’s low levels of nicotinamide adenine dinucleotide (NAD+). These factors include

1. Aging: NAD+ levels naturally decline with age due to reduced synthesis and increased consumption. This decline is associated with decreased cellular energy production, impaired DNA repair, and increased susceptibility to age-related diseases.

2. Poor Diet: Inadequate niacin intake (vitamin B3), a precursor to NAD+, can lead to lower NAD+ levels. 

3. Stress and Inflammation: Chronic stress and inflammation can deplete NAD+ levels. These conditions increase the demand for NAD+ in various cellular processes, reducing availability for energy production and other vital functions.

4. Lifestyle Factors: A sedentary lifestyle, poor sleep patterns, and unhealthy eating habits can collectively contribute to lower NAD+ levels by affecting cellular metabolism and energy production.

5. Genetic Factors: Genetic variations can affect the enzymes involved in NAD+ synthesis, recycling, and consumption. 

6. Environmental Toxins: Exposure to environmental toxins, such as pesticides and pollutants, can interfere with NAD+ metabolism and contribute to its depletion.

7. Certain Medications: Some medications, like certain chemotherapy drugs, may interfere with NAD+ metabolism and contribute to its depletion.

Signs of insufficient NAD levels

1. Fatigue and Reduced Energy: Low NAD+ levels can result in reduced ATP production, leading to feelings of fatigue and low energy levels.

2. Muscle Weakness: Insufficient NAD+ can impair mitochondrial function, contributing to muscle weakness and decreased physical performance.

3. Cognitive Decline: Inadequate levels of NAD+ may be associated with cognitive decline, memory problems, and an increased risk of neurodegenerative diseases.

4. DNA Damage and Impaired Repair: Insufficient NAD+ can hinder the body’s ability to repair DNA damage, potentially leading to increased susceptibility to mutations and cellular dysfunction.

5. Accelerated Aging: Low NAD+ levels can impact sirtuin function, contributing to accelerated aging.

6. Metabolic Dysfunction: Inadequate NAD+ levels can disrupt metabolic pathways, potentially leading to insulin resistance, weight gain, and metabolic disorders.

7. Increased Sensitivity to Stress: Low NAD+ levels may result in reduced resilience to oxidative stress and an impaired ability to cope with environmental stressors.

8. Impaired Immune Function: Insufficient NAD+ can lead to compromised immune responses, making the body more susceptible to infections and inflammatory conditions.

9. Mood Disorders: Decreased NAD+ levels might contribute to mood disorders such as depression and Anxiety.

10. Altered Circadian Rhythms: Disrupted NAD+ levels can lead to irregular sleep patterns and disturbances in the body’s internal clock.

How NAD Helps Ease Anxiety Symptoms

1. Neurotransmitter Function: NAD synthesizes neurotransmitters like serotonin, dopamine, and GABA, which play vital roles in mood regulation. An imbalance in these neurotransmitters is often associated with anxiety disorders.

2. Mitochondrial Function: NAD is a key component in the electron transport chain, the process by which cells generate energy. Proper energy production is essential for optimal brain function and reducing stress-related symptoms.

3. Cellular Repair: NAD is required for DNA repair processes, which are critical for maintaining the health and function of neurons. Healthy neurons improve cognitive function and emotional regulation, potentially reducing anxiety symptoms.

4. Sirtuin Activation: NAD is a cofactor for sirtuins, a protein group that regulates cellular stress responses and promotes resilience against oxidative stress. By supporting sirtuin activity, NAD may indirectly reduce anxiety-related cellular damage.

5. Inflammation Regulation: Chronic inflammation has been linked to anxiety and mood disorders. NAD’s role in regulating inflammation could improve the overall emotional state.

6. Stress Resilience: NAD helps modulate the body’s stress response by influencing the hypothalamic-pituitary-adrenal (HPA) axis, which releases stress hormones like cortisol.

7. NAD Supplements: Some individuals use NAD supplements to enhance their mental well-being. However, research on NAD supplementation’s direct impact on Anxiety is limited, and its effectiveness can vary.

What is the role of NAD+ IV infusions in managing Anxiety?

NAD+ IV infusions support mental health by improving cellular function and reducing oxidative stress that triggers anxiety. This treatment can either be a sole treatment or complement traditional approaches such as therapy and medication.

Anxiety is a complex and pervasive mental health concern that has become increasingly prevalent. The 2018 poll’s staggering statistic, where 74% of individuals admitted to feeling overwhelmed or unable to cope due to stress, underscores the widespread impact of anxiety. 

NAD IV therapy is vital in managing anxiety disorder as it reduces anxiety symptoms and promotes mental wellness. Following an IV therapy routine allows the brain to generate the necessary components. 

NAD IV treatment also enhances cellular energy production and optimizes neurotransmitter function. This dual mechanism has the potential to positively influence mood regulation, providing patients with a holistic approach to managing their anxiety symptoms.

The advantages of IV therapy stem from its direct introduction and retention of fluids within your bloodstream, promptly providing the desired effects. The IV therapy formula is painless and effective in managing anxiety disorders.

However, it’s important to note that potential side effects encompass brief breathlessness or heightened heart rate. These effects are generally benign and might persist for several seconds to a few minutes post-injection.

Before considering NAD+ IV infusions or any alternative treatments, prioritizing your health and well-being should always be at the forefront of your decisions. Consulting with a qualified medical professional empowers you to make informed choices aligned with the latest medical insights. 

However, your pursuit of a healthier life doesn’t have to end there. Subscribing to BetterHelp opens up a platform full of experienced therapists, ready to assist you in managing your anxiety.


1. Does NAD+ increase serotonin?

NAD+ (nicotinamide adenine dinucleotide) is not directly involved in the production or regulation of serotonin, a neurotransmitter that affects mood and well-being.

However, NAD+ does play a role in various cellular processes, including energy production and DNA repair, which can indirectly influence neurotransmitter balance.

2. What does NAD+ do for the brain?

NAD+ is crucial for brain health as it supports energy production in brain cells, helps maintain the integrity of DNA, and supports cellular repair processes.

It’s also involved in the function of enzymes and proteins related to cognition, memory, and overall brain function.

3. How long does it take for NAD+ to start working?

The time it takes for NAD+ supplementation to show noticeable effects can vary depending on the individual and the specific reason for its use.

Some people might experience changes in energy levels and cognitive function within days to weeks, while others might require longer periods of consistent supplementation to see results.

4. Is it safe to take NAD+ daily?

NAD+ supplements are generally considered safe when taken within recommended dosages. However, it’s important to consult a healthcare professional before starting any new supplement regimen, especially daily.

They can provide personalized advice based on your health profile and potential interactions with other medications or conditions.

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