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Skyrizi, known by its generic name risankizumab, has emerged as a highly effective medication for individuals suffering from chronic inflammatory diseases like plaque psoriasis and psoriatic arthritis.

With its ability to alleviate the symptoms and improve the quality of life for patients, Skyrizi has gained significant recognition and is increasingly prescribed by healthcare professionals.

However, as with any medication, there have been concerns raised regarding the potential impact of Skyrizi on mental health, specifically its association with the development of depression.

This article aims to provide a comprehensive exploration of the topic by delving into Skyrizi’s mechanism of action, investigating the relationship between Skyrizi and depression, analyzing existing research findings, and emphasizing the crucial significance of closely monitoring mental health during Skyrizi treatment.

Skyrizi: An Overview

Skyrizi is an interleukin-23 (IL-23) inhibitor that has been approved for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis. It belongs to a class of drugs that specifically target the inflammatory pathways involved in autoimmune diseases.

Plaque psoriasis is a chronic autoimmune condition characterized by red, scaly patches on the skin, while psoriatic arthritis is a form of arthritis that affects individuals with psoriasis, causing joint pain, swelling, and stiffness.

Skyrizi effectively addresses the symptoms of these conditions by specifically targeting and inhibiting IL-23, a protein that plays a crucial role in the inflammatory response.

Skyrizi is available as a subcutaneous injection (under the skin) and is typically administered by a healthcare professional or as instructed by a healthcare provider. The recommended dose is an initial loading dose of two 150 mg injections, followed by maintenance doses of 150 mg every 12 weeks.

Like any medication, Skyrizi may cause certain side effects. Common side effects may include upper respiratory infections, headache, fatigue, injection site reactions, and fungal infections.

Depression: Understanding the Mental Health Condition

Depression is a complex mental health disorder that affects millions of people worldwide. It is characterized by persistent feelings of sadness, hopelessness, and a loss of interest or pleasure in activities that were once enjoyable. Individuals with depression may also experience changes in appetite, sleep disturbances, fatigue, difficulty concentrating, and thoughts of self-harm or suicide.

The exact cause of depression remains unclear, but it is believed to involve a combination of genetic, environmental, and biochemical factors. Imbalances in neurotransmitters such as serotonin, norepinephrine, and dopamine, which play crucial roles in regulating mood and emotions, are often observed in individuals with depression.

Depression can significantly impact a person’s overall well-being, relationships, and daily functioning. It is essential to recognize the importance of mental health and address any concerns that may arise during the course of treatment with medications such as Skyrizi.

The Mechanism of Skyrizi and Depression

skin allergy
Image Credit: healthline.com

a. Skyrizi’s Mechanism of Action: 

Skyrizi works by specifically targeting and inhibiting the activity of interleukin-23 (IL-23), a pro-inflammatory cytokine that is implicated in chronic inflammatory diseases such as plaque psoriasis and psoriatic arthritis.

By inhibiting IL-23, Skyrizi helps to reduce the excessive inflammation and immune responses associated with these conditions, leading to improved symptoms and quality of life for patients.

b. The Neurobiology of Depression

Depression is thought to involve dysregulation of various neurotransmitters in the brain, including serotonin, norepinephrine, and dopamine.

These neurotransmitters play essential roles in regulating mood, emotions, and motivation. Imbalances in these chemicals can contribute to the development and persistence of depressive symptoms.

While the exact mechanisms underlying depression and its relationship with Skyrizi remain unclear, it is important to consider the potential impact of medications on neurotransmitter activity and the intricate interplay between inflammatory processes and mental health.

It is worth noting that depression can also be influenced by factors such as genetic predisposition, environmental stressors, personal circumstances, and the presence of other medical conditions.

Therefore, any potential link between Skyrizi and depression should be evaluated within the broader context of individual patient characteristics and disease severity.

Research on Skyrizi and Depression

To address concerns regarding Skyrizi’s potential impact on mental health, various research studies, clinical trials, and post-marketing surveillance have been conducted.

These endeavors aim to examine the incidence of depression among individuals receiving Skyrizi treatment and compare it to those receiving a placebo or alternative therapies.

a. Clinical Studies

Numerous clinical trials have been conducted to evaluate the safety and efficacy of Skyrizi for the treatment of plaque psoriasis and psoriatic arthritis. While depression has been reported as an adverse event in some trials, it is important to consider that the incidence of depression in patients receiving Skyrizi was comparable to those receiving a placebo or alternative treatments.

These findings suggest that depression may not be directly caused by Skyrizi but could be a result of the underlying conditions being treated.

b. Post-Marketing Surveillance

Post-marketing surveillance involves monitoring the safety and side effects of a medication after it has been approved and released to the market. Reports from post-marketing data on Skyrizi do not indicate a significant association between the medication and an increased risk of depression. 

c. The Influence of Chronic Conditions

Chronic inflammatory diseases such as plaque psoriasis and psoriatic arthritis can have a profound impact on mental health. The physical manifestations, discomfort, and functional limitations associated with these conditions can contribute to the development or worsening of depression.

Therefore, it is crucial to consider the potential confounding factors associated with the diseases themselves when evaluating the relationship between Skyrizi and depression.

d. Real-World Patient Reports

Since Skyrizi received FDA approval and became available for prescription, in online forums and reviews a few patients have written about changes in mood, lack of motivation, difficulty sleeping, and feelings of depression within weeks of starting Skyrizi treatment. However, not all patients report these side effects.

It’s difficult to determine the cause of these reported depression symptoms based only on a few patients’ reviews, since Skyrizi does appear to be well-tolerated for most patients, with low risks of serious side effects based on clinical studies.

However, as with any new medication, ongoing monitoring for adverse effects is needed—especially longer-term effects that may not appear until months or years after the drug has been on the market. 

Researchers and regulatory agencies continue to track the safety profile of Skyrizi to ensure there are no significant psychological side effects or impacts on patient wellbeing.

Reporting any suspected side effects is encouraged to help support a better understanding of this medication’s influence on depression and other conditions.

Consultation and Monitoring

Given the potential concerns surrounding Skyrizi and depression, it is essential for healthcare providers need to have discussions with patients. Before initiating Skyrizi treatment, patients should be screened for a history of mental health conditions, including depression.

Regular monitoring of patients’ mental health during treatment is crucial to promptly identify any changes or worsening of depressive symptoms.

If depressive symptoms arise or worsen, appropriate interventions and support should be provided, which may include referral to mental health professionals for further evaluation and treatment.


Based on current research, there is no substantial evidence to suggest that Skyrizi directly causes depression. The reported cases of depression are comparable to those in patients receiving a placebo or alternative treatments.

It is essential to consider the potential impact of underlying chronic conditions and the complex interplay between mental health and inflammatory diseases.

Healthcare providers should engage in proactive discussions and monitoring, ensuring that patients receive comprehensive care for both their physical and mental well-being.


Are individuals taking Skyrizi at a higher risk of developing depression compared to those on other treatments?

Studies have shown that the incidence of depression in patients receiving Skyrizi is comparable to those receiving a placebo or alternative treatments, suggesting that Skyrizi does not pose a significantly higher risk of depression.

What are the common side effects of Skyrizi, and do they include depression?

Common side effects of Skyrizi include upper respiratory tract infections, headache, fatigue, and gastrointestinal symptoms.

While depression has been reported as an adverse event, its incidence is not higher than that observed in patients receiving a placebo or alternative treatments.

How can Skyrizi, a medication primarily used to treat skin and joint conditions, impact mental health?

Skyrizi’s impact on mental health is likely indirect. By effectively managing chronic inflammatory diseases such as plaque psoriasis and psoriatic arthritis, Skyrizi may alleviate the physical manifestations, discomfort, and functional limitations associated with these conditions, which can in turn have a positive impact on mental well-being.

Are there any specific warning signs or symptoms of depression that patients should be aware of while on Skyrizi?

Patients should be aware of common symptoms of depression, such as persistent feelings of sadness, loss of interest or pleasure, changes in appetite or sleep patterns, fatigue, difficulty concentrating, and thoughts of self-harm or suicide. If any of these symptoms arise or worsen, it is important to seek medical attention promptly.

Are there any known interactions between Skyrizi and antidepressant medications?

There are no known interactions between Skyrizi and antidepressant medications. However, healthcare providers need to be aware of all medications a patient is taking to ensure comprehensive and safe treatment.

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  5. Best Ways to Cure Depression



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