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Depression is a complex mental health condition that affects millions of people worldwide. It can cause persistent feelings of sadness, hopelessness, and a lack of interest in activities once enjoyed.

While there are various treatment options available, including therapy and medication, some individuals seek alternative approaches to managing depression. One such avenue gaining attention is the potential use of mushrooms.

Mushrooms have long been revered for their medicinal properties and have been used in traditional medicine systems for centuries. Recent research has shed light on specific types of mushrooms that may hold promise in alleviating depressive symptoms and promoting mental well-being.

It is important to note that while mushrooms may offer potential benefits for depression, they should not replace professional medical advice or conventional treatment methods.

Always consult with a healthcare provider before incorporating any new supplements or alternative therapies into your depression management plan.

Best mushrooms for depression

Following are some mushrooms that have been shown to be effective for the treatment of depression.

1. Psilocybin mushrooms

Psilocybin mushrooms, commonly known as “magic mushrooms,” have gained attention for their potential therapeutic benefits in treating depression. These mushrooms contain psilocybin, a hallucinogenic compound that produces altered perceptions and a range of psychological effects. 

When using magic mushrooms for depression, there are various consumption methods. They can be eaten raw, ground up, and mixed with lemon, boiled into tea, taken in capsules, or crushed into a fine powder and snorted. 

The psychedelic experience induced by magic mushrooms often includes feelings of peacefulness, transformative healing, connectedness, increased self-compassion, new insights into oneself, a sense of meaning, creativity, adaptability, altered perception, and optimism.

Psilocybin-assisted therapy (PAT): One area of promising research involves the use of psilocybin-assisted therapy (PAT) for individuals with treatment-resistant depression. This therapy involves the guided use of magic mushrooms in a controlled clinical setting, under the supervision of a licensed psychotherapist. 

The primary aim of PAT is to provide a supportive environment for individuals to undergo transformation through the use of psilocybin. This approach is distinct from recreational use, as the treatment protocol is carefully designed and overseen by a professional.

One significant advantage of PAT is the integration of psychotherapy with the psychedelic experience. A licensed therapist helps prepare and guide individuals through the session, ensuring they feel safe and supported throughout the process. 

This is particularly important for first-time users, as the experience of ego dissolution can be intense and potentially frightening. With the therapist’s assistance, individuals can explore the underlying causes of their depression and gain insights into their thoughts, emotions, and behaviors.

In addition to the psychological support provided during the session, PAT offers another crucial benefit: safety. Prior to starting the therapy, individuals undergo a comprehensive screening process to assess their medical and psychiatric history.

This is to identify any conditions or risk factors that could potentially be exacerbated by the psychedelic experience.

Image Credit: healthcare.utah.edu

2. Lion’s Mane mushroom

Lion’s Mane mushroom (Hericium erinaceus) is a unique and fascinating species of mushroom known for its distinctive appearance and potential health benefits. This mushroom gets its name from its resemblance to the mane of a lion, with long, shaggy white tendrils cascading down from the mushroom’s base. 

While it has been used for centuries in traditional Chinese medicine, recent scientific research has shed light on its potential benefits for various aspects of health, including mental well-being and the management of depression.

Lion’s Mane mushroom has also been found to elevate the presence of pro-BDNF (brain-derived neurotrophic factor) in the bloodstream, which can be converted into the active form known as BDNF. The conversion of pro-BDNF to BDNF is crucial for maintaining cognitive function and mental well-being. 

Disruptions in this conversion process have been associated with cognitive decline, psychiatric disorders, and anxiety-related behaviors.

Therefore, the consumption of Lion’s Mane mushrooms holds promise in promoting a healthy balance and potentially enhancing cognitive abilities and mental health by facilitating the proper conversion of pro-BDNF into BDNF.

Lion’s Mane mushroom is commonly available in various forms, including capsules, powders, and extracts. It can be consumed as a dietary supplement or incorporated into recipes and beverages.

The appropriate dosage may vary depending on the individual and the specific product, so it’s essential to follow the recommended guidelines provided by the manufacturer or healthcare professional.

While Lion’s Mane mushroom is generally considered safe for consumption, some individuals may experience mild gastrointestinal discomfort or allergic reactions. As with any supplement, it’s important to purchase from reputable sources and ensure product quality and purity.

3. Reishi mushrooms

Reishi mushrooms, scientifically known as Ganoderma lucidum, are renowned for their robust appearance, featuring a kidney-shaped cap and a glossy reddish-orange color. Referred to as the “mushroom of immortality” or lingzhi, these mushrooms have been utilized in traditional Asian medicine and cuisine for over two millennia. 

They have shown efficacy in enhancing immune function, guarding against viral infections, and impeding the growth and progression of cancer cells and tumors, including breast, prostate, and colorectal cancers.

Additionally, Reishi mushrooms exhibit the potential in alleviating anxiety and depression, reduce stress levels, improve sleep quality, and promote cognitive well-being.

Finding whole Reishi mushrooms can be challenging due to their tough and woody texture. However, they can be sourced from Asian markets or obtained in alternative forms such as powdered, capsules, or tinctures.

To incorporate Reishi mushrooms into your culinary repertoire, it is advisable to pair them with robust herbs and spices to mask their inherent bitterness.

One approach is to simmer dried slices of Reishi mushrooms with garlic, ginger, and onions, subsequently straining the concoction to create a nourishing broth or soup base.

4. Cordyceps mushrooms

Cordyceps mushrooms, scientifically known as Cordyceps sinensis, are a unique combination of a deceased caterpillar and fungal stromata.

While not classified as a mushroom in taxonomical terms, Cordyceps has been recognized as a medicinal mushroom in Traditional Chinese Medicine (TCM) and Tibetan practices. 

For thousands of years, Cordyceps has been utilized in Asian medicine to address issues such as fatigue, enhance libido, and boost energy levels. Cordyceps also contains adenosine, a compound known for its heart-protective properties.

Nowadays, Cordyceps can be easily consumed in the form of supplements, such as capsules, allowing individuals to reap its health benefits conveniently.

A recent study conducted in 2020 demonstrated that rats administered high concentrations of Cordyceps and poria (another adaptogenic mushroom) exhibited reduced depression and anxiety responses to “mild stressors” compared to a control group.

Based on these findings, the researchers concluded that Cordyceps and other mushrooms of its kind could potentially be beneficial in preventing depression and anxiety in humans as well.

It is important to note that the use of mushrooms for depression should only be pursued under the guidance of a licensed professional in a legal and controlled setting. Self-medication or recreational use without appropriate supervision can carry risks and may not provide the same therapeutic benefits. 


As we conclude our exploration of the best mushrooms for depression, it becomes evident that these natural wonders hold immense potential in supporting mental health and well-being.

From the mind-expanding effects of psilocybin mushrooms to the immune-boosting and mood-regulating properties of Lion’s Mane and Reishi mushrooms, the realm of fungi offers a fascinating array of therapeutic possibilities.

However, it is important to remember that mushrooms are not a standalone solution for depression. They should be considered as part of a comprehensive approach that includes therapy, lifestyle modifications, and other evidence-based treatments.


Can anyone use mushrooms for depression?

The use of mushrooms for depression may not be suitable for everyone. Individuals with certain medical conditions, such as hypertension, heart disease, schizophrenia, bipolar disorder, or alcoholism, may be at higher risk and should avoid using mushrooms without proper medical guidance. 

Pregnant or breastfeeding individuals should also avoid using mushrooms due to limited research on their safety during these periods. Certain mushrooms may also have legal restrictions in some countries or regions.

It is essential to consult with healthcare professionals to determine the appropriateness of mushroom use based on individual circumstances.

How long does it take for mushrooms to show an effect on depression?

The timeline for experiencing the effects of mushrooms on depression can vary. In the case of psilocybin-assisted therapy, which is conducted under professional guidance, individuals may start to notice improvements in their symptoms after a few sessions.

However, the effects can vary depending on factors such as dosage, individual response, and the overall treatment plan.

Are there any side effects or risks associated with using mushrooms for depression?

While mushrooms can offer therapeutic benefits, they are not without potential risks. Psychedelic mushrooms, in particular, can induce intense experiences and may not be suitable for everyone.

It is essential to use mushrooms responsibly, follow recommended dosages, and seek guidance from healthcare professionals to minimize potential risks and ensure a safe experience.

Are there any contraindications or interactions with medications?

Yes, mushrooms, particularly those with psychoactive properties, can interact with certain medications. It is crucial to inform healthcare professionals about all medications, supplements, or herbs you are taking to ensure there are no contraindications or potential adverse interactions.

A thorough evaluation of your medical history and current medication regimen is important before using a mushroom.

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